abstract：:A new compound derivative of glycoside 19-α-hydroxy-ursolic acid glucoside (19-α-hydroxyurs-12(13)-ene-28-oic acid-3-O-β-D-glucopyranoside (HEG) was isolated from whole plant of Wedelia calendulacea (Compositae). The structure was elucidated and established by standard spectroscopy approaches. Diethylnitrosamine (DEN)...

journal_title：Inflammopharmacology

authors： Verma A,Ahmed B,Anwar F,Rahman M,Patel DK,Kaithwas G,Rani R,Bhatt PC,Kumar V

更新日期：2017-02-01 00:00:00

abstract：:Kerabala (CB) is a novel ayurvedic formulation used for treating various inflammatory diseases. This formulation was made from virgin coconut oil and it comprises extracts of Sida cordifolia, coconut milk and sesame oil. The current study was performed to evaluate the anti-inflammatory action of CB on carrageenan-indu...

journal_title：Inflammopharmacology

authors： Ratheesh M,Sandya S,Pramod C,Asha S,Svenia JP,Premlal S,GrishKumar B

更新日期：2017-02-01 00:00:00

abstract：:TRP channels have been discovered as a specialized group of somatosensory neurons involved in the detection of noxious stimuli. Desensitization of TRPV1 located on dorsal root and trigeminal ganglia exhibits analgesic effect and makes it potential therapeutic target for treatment of neuropathic pain. With this backgro...

journal_title：Inflammopharmacology

authors： Marwaha L,Bansal Y,Singh R,Saroj P,Sodhi RK,Kuhad A

更新日期：2016-12-01 00:00:00

abstract：:Chronic inflammation is a world health problem. There is a need to develop new anti-inflammatory and analgesic drugs with improved activity and reduced side effects. In this context, the aim of this study was to evaluate the antinociceptive and anti-inflammatory effects of the pyrazole compound LQFM-021 after acute an...

journal_title：Inflammopharmacology

authors： Florentino IF,da Silva DP,Martins JL,da Silva TS,Santos FC,Tonussi CR,Vasconcelos GA,Vaz BG,Lião LM,Menegatti R,Costa EA

更新日期：2016-10-01 00:00:00

abstract：AIM:Experimental autoimmune encephalomyelitis (EAE) is a CD4(+)-mediated autoimmune pathology of the central nervous system (CNS) that is used as a model for the study of the human neuroinflammatory disease, multiple sclerosis. During the development of EAE, auto-reactive Th1 and Th17 CD4(+) T cells infiltrate the CNS ...

journal_title：Inflammopharmacology

authors： de Oliveira DM,de Oliveira EM,Ferrari Mde F,Semedo P,Hiyane MI,Cenedeze MA,Pacheco-Silva A,Câmara NO,Peron JP

更新日期：2015-12-01 00:00:00

abstract：:The aim of the study was to evaluate the effect of Pterocarpus marsupium (PM) on acetic acid (AA)-induced ulcerative colitis (UC) in rats. The rats were divided into five groups, each having six rats. PM extract 100 mg and 200 mg/kg was given orally to groups four and five, respectively, and standard drug sulfasalazin...

journal_title：Inflammopharmacology

authors： Mathew MM,Han NV,Murugesan A,Raj EA,Prasanth KG

更新日期：2015-08-01 00:00:00

abstract：:There is a growing body of evidence that plant polyphenols such as resveratrol, anthocyanins, catechins, and terpenes like taxol are effectively used in the treatment of chronic conditions including cancer, Alzheimer, Parkinsonism, diabetes, aging, etc. The link between oxidative stress and inflammation is well accept...

journal_title：Inflammopharmacology

authors： Afzal M,Safer AM,Menon M

更新日期：2015-08-01 00:00:00

abstract：:A small GTPase, Rac1, is recognized as an important modulator of the inflammatory responses to bacterial lipopolysaccharide (LPS) by affecting the processes of phospholipase C activation. The activation of Rac1 involves the exchange of GDP for GTP and is catalyzed by the guanine nucleotide exchange factors (GEFs). Her...

journal_title：Inflammopharmacology

authors： Slomiany BL,Slomiany A

更新日期：2015-06-01 00:00:00

abstract：:Neuropathic pain triggers a cascade of events in the sensory neurons. It is the main complication of diabetes after cardiovascular disease. Nitric oxide (NO) produced from nitric oxide synthases (NOS) is an important signaling molecule which is crucial for many physiological processes such as synaptic plasticity, neur...

journal_title：Inflammopharmacology

authors： Ahlawat A,Rana A,Goyal N,Sharma S

更新日期：2014-10-01 00:00:00

abstract：:Central nervous system (CNS) has a completely separate immune system that communicates with the neurons by small molecules called cytokines. Cytokines are involved in many crucial processes in neuron including cell metabolism and neurotransmitter synthesis. It has been reported that cytokine imbalance is involved in t...

journal_title：Inflammopharmacology

authors： Al-Amin MM,Uddin MM,Rahman MM,Reza HM,Rana MS

更新日期：2013-12-01 00:00:00

abstract：:Euphorbia hirta L. (Euphorbiaceae) (E. hirta) is a tree locally used as a traditional medicine in Africa and Australia to treat numerous diseases such as hypertension, respiratory ailments, tumors, antipyretic, anti-inflammatory activities. In the present study, we investigated the anti-arthritic activity of fresh lea...

journal_title：Inflammopharmacology

authors： Fayaz Ahmad S,Sultan P,Ashour AE,Khan TH,Attia SM,Bakheet SA,Abd-Allah AR

更新日期：2013-10-01 00:00:00

abstract：:Caffeic acid phenethyl ester (CAPE) is the active component of honey bee propolis extracts. The results of the current study demonstrate that CAPE attenuated immunoglobulin (Ig)E-mediated allergic response in mast cells. Oral administration of CAPE inhibited IgE-mediated passive cutaneous anaphylaxis. CAPE effectively...

journal_title：Inflammopharmacology

authors： Nader MA

更新日期：2013-04-01 00:00:00

abstract：:Euphorbia hirta L. (Euphorbiaceae) (E. hirta) is a tree locally used as a traditional medicine in Africa and Australia to treat numerous diseases such as hypertension, respiratory ailments, tumors, wounds, antipyretic, anti-inflammatory activities, etc. Therefore, we undertook to investigate their immunomodulatory eff...

journal_title：Inflammopharmacology

authors： Ahmad SF,Khan B,Bani S,Kaul A,Sultan P,Ali SA,Satti NK,Bakheet SA,Attia SM,Zoheir KM,Abd-Allah AR

更新日期：2013-04-01 00:00:00

abstract：:The up-regulation of angiotensin II AT1 receptors has been implicated as a major mediator in the development of hypertension and progressive nephropathy in experimental diabetes. In spite of the documented potential of garlic treatments in ameliorating diabetic complications, the possible involvement of the angiotensi...

journal_title：Inflammopharmacology

authors： Mansour MH,Al-Qattan K,Thomson M,Ali M

更新日期：2013-04-01 00:00:00

abstract：:Allanblackia gabonensis (Guttiferae) is a plant used in the African traditional medicine as remedies against pain, rheumatism, inflammations. In the present work, the analgesic effect of aqueous extract has been evaluated using acetic acid, formalin, hot-plate test, tail immersion and paw-pressure test. The anti-infla...

journal_title：Inflammopharmacology

authors： Ymele EV,Dongmo AB,Dimo T

更新日期：2013-02-01 00:00:00

abstract：:The idea that microbes induce disease has steered medical research toward the discovery of antibacterial products for the prevention and treatment of microbial infections. The twentieth century saw increasing dependency on antimicrobials as mainline therapy accentuating the notion that bacterial interactions with huma...

journal_title：Inflammopharmacology

authors： Vitetta L,Briskey D,Hayes E,Shing C,Peake J

更新日期：2012-10-01 00:00:00

abstract：:Biologic disease modifying anti-rheumatic drugs have transformed the management of rheumatoid arthritis (RA) since their introduction into clinical practice over a decade ago. Following large-scale clinical trials, a number of biologics, with different mechanisms of action, have been licensed for the condition. In thi...

journal_title：Inflammopharmacology

authors： Malaviya AP,Ostör AJ

更新日期：2012-04-01 00:00:00

abstract：OBJECTIVE:This pilot study aimed to determine the efficacy of acamprosate (N-acetyl homotaurine) in reducing the pathological features of experimental autoimmune encephalomyelitis (EAE) which is an animal model for multiple sclerosis (MS). BACKGROUND:The amino acid taurine has multiple biological activities including ...

journal_title：Inflammopharmacology

authors： Sternberg Z,Cesario A,Rittenhouse-Olson K,Sobel RA,Leung YK,Pankewycz O,Zhu B,Whitcomb T,Sternberg DS,Munschauer FE

更新日期：2012-02-01 00:00:00

abstract：:Propolis is a resinous substance collected by honeybees from leaf buds and cracks in the bark of various plants. Propolis has been reported to have immunomodulatory activity. We hypothesized that propolis would be able to reduce the disease severity of rheumatoid arthritis. We evaluated the effect of Brazilian propoli...

journal_title：Inflammopharmacology

authors： Tanaka M,Okamoto Y,Fukui T,Masuzawa T

更新日期：2012-02-01 00:00:00

abstract：:This review considers the problem of the serious concomitant side effects of powerful anti-inflammatory drugs modelled upon the principal human glucocorticoid hormone, cortisol. The very nature of the original bio-assays to validate their cortisol-like hormonal and anti-inflammatory activities ensured that pleiotropic...

journal_title：Inflammopharmacology

authors： Whitehouse MW

更新日期：2011-02-01 00:00:00

abstract：:The aim of this study was to investigate the effect of the nitric oxide donor isosorbide-5-mononitrate (5-ISMN) alone or in combination with the natural hepatoprotectant with anti-oxidant activity silymarin on the carbon tetrachloride (CCl(4))-induced hepatic injury in rats. 5-ISMN (1.8, 3.6 or 7.2 mg/kg), silymarin (...

journal_title：Inflammopharmacology

authors： Abdel Salam OM,Sleem AA,Shafee N

更新日期：2010-04-01 00:00:00

abstract：AIM:Activation of sphingosine kinase (SK) is a key response to many inflammatory processes. The present studies test the hypothesis that an orally available SK inhibitor, ABC294640, would be effective in rodent models of Crohn's disease. METHODS:Trinitrobenzene sulfonic acid (TNBS) was administered rectally to mice an...

journal_title：Inflammopharmacology

authors： Maines LW,Fitzpatrick LR,Green CL,Zhuang Y,Smith CD

更新日期：2010-04-01 00:00:00

abstract：:Based on a unifying theory presented here, it is predicted that the immune defects resulting in chronic inflammation rather than effective immune responses could be rectified by the therapeutic use of agents prepared from micro-organisms. With appropriate molecular patterns, these should be able to induce protective i...

journal_title：Inflammopharmacology

authors： Bottasso O,Docena G,Stanford JL,Grange JM

更新日期：2009-08-01 00:00:00

abstract：:The effect of lupeol, a natural pentacyclic triterpene on ethanol-induced gastric damage in mice was evaluated. The gastroprotection was assessed by determination of changes in mean gastric lesion area, quantification of mucosal non-protein sulfhydryls (NP-SH), and characterized using drugs that influence the endogeno...

journal_title：Inflammopharmacology

authors： Lira SR,Rao VS,Carvalho AC,Guedes MM,de Morais TC,de Souza AL,Trevisan MT,Lima AF,Chaves MH,Santos FA

更新日期：2009-08-01 00:00:00

abstract：:Pain is recognized as a multifactorial sensory experience that is wholly unpleasant. It can vary in intensity from mild to severe and its duration can be anything from transient to persistent. Today we know so much more about the peripheral nociceptor as the primary detection apparatus for painful stimuli. We also und...

journal_title：Inflammopharmacology

authors： Rodger IW

更新日期：2009-06-01 00:00:00

abstract：AIM:The capture, analysis and utilisation of health status information are attended by logistic considerations and interpretation challenges. We report a preliminary evaluation of cellular technology in capturing WOMAC NRS 3.1 Index data. METHODS:A Java midlet for delivering the WOMAC NRS3.1 Index on Nokia-6300, Motor...

journal_title：Inflammopharmacology

authors： Bellamy N,Wilson C,Hendrikz J,Patel B,Dennison S

更新日期：2009-04-01 00:00:00

abstract：OBJECTIVE:To evaluate the potential of Azadirachta indica leaf extracts against Salmonella typhimurium-induced inflammation in BALB/c mice. DESIGN:Qualitative tests of A. indica leaf extracts were conducted for screening of various phytochemicals. The antiinflammatory potential of A. indica leaf extracts on S. typhimu...

journal_title：Inflammopharmacology

authors： Koul A,Bharrhan S,Singh B,Rishi P

更新日期：2009-02-01 00:00:00

abstract：:Regular moderate wine consumption is often associated with reduced morbidity and mortality from to a variety of chronic diseases in which inflammation is a root cause. Wine comes in a wide variety of styles that contain quite different ethanol and polyphenol contents. Controversy remains as to whether the alcohol or p...

journal_title：Inflammopharmacology

authors： Walzem RL

更新日期：2008-12-01 00:00:00

abstract：:Genistein is an isoflavone with oestrogenic activity that is present in a variety of soy products as a constituent of complex mixtures of bioactive compounds, whose matrix profiles play an important role in determining the overall oestrogenic bioactivity of genistein. We review data on how the profile of soy bioactive...

journal_title：Inflammopharmacology

authors： Helferich WG,Andrade JE,Hoagland MS

更新日期：2008-10-01 00:00:00

abstract：:In the process of the oxygen reduction, NADPH oxidase is the enzyme that produces superoxide anion, which subsequently produces reactive oxygen species (ROS) and causes damage in various tissues and microorganisms. NADPH oxidase is demonstrated to exist in several types of cells such as endothelial cells and vascular ...

journal_title：Inflammopharmacology

authors： Nakagiri A,Sunamoto M,Murakami M

更新日期：2007-12-01 00:00:00

abstract：:To clarify roles of H2S in regulation of gastric circulation, we investigated effects of NaHS, a H2S donor, on tension of isolated rat gastric artery and gastric mucosal blood flow in rats. In the precontracted ring preparations, NaHS caused contraction and relaxation at low and high concentrations, respectively. The ...

journal_title：Inflammopharmacology

authors： Kubo S,Kajiwara M,Kawabata A

更新日期：2007-12-01 00:00:00

abstract：:The inflamed mucosa in ulcerative colitis produces high amount of prostaglandin (PG) and nitric oxide (NO) through inducible enzymes: cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS), respectively, implicating them as potential anti-inflammatory drug targets. COX-2 or iNOS-related treatments in diff...

journal_title：Inflammopharmacology

authors： Dudhgaonkar SP,Tandan SK,Kumar D,Raviprakash V,Kataria M

更新日期：2007-10-01 00:00:00

abstract：:Ischemia/reperfusion (I/R) damages gastric mucosa via reactive oxygen species (ROS) activity. ROS was reportedly produced through angiotensin II stimulation in tissues such as kidney, heart and brain. To determine whether AT1 receptor plays a role in gastric mucosal damage, we examined the effect of AT1 receptor block...

journal_title：Inflammopharmacology

authors： Nakagiri A,Sunamoto M,Murakami M

更新日期：2007-08-01 00:00:00

abstract：:The intestinal mucosa is subject to a variety of physical forces in a complex manner during normal gut function and in disease. Intestinal mucosal atrophy during some disease states is a troubling phenomenon that is only partially explained by nutritional parameters. Increasing evidence suggests the possibility that r...

journal_title：Inflammopharmacology

authors： Basson MD

更新日期：2007-06-01 00:00:00

abstract：:Most of the gastroprotective drugs which had been marketed in Japan were considered to have insufficient rationale for use as ulcer treatments. Such drugs may have a crucial role in maintaining mucosal integrity by the mechanisms other than inhibition of acid secretion. We re-evaluated the effect of gastroprotective d...

journal_title：Inflammopharmacology

authors： Higuchi K,Watanabe T,Tanigawa T,Shiba M,Tominaga K,Fujiwara Y,Oshitani N,Arakawa T

更新日期：2007-02-01 00:00:00

abstract：:Inflammatory bowel diseases are associated with reduced colonic contractility and induction of cyclooxygenase-2. In this study a possible role of cyclooxygenase-2 in and the underlying mechanism of the reduced contractility were investigated in experimental colitis. The effects of meloxicam, a cyclooxygenase-2 selecti...

journal_title：Inflammopharmacology

authors： Khan I,Oriowo MA

更新日期：2006-03-01 00:00:00

abstract：OBJECTIVE:To study the effect of hyaluronan on cell adhesion and recruitment both in vitro and in vivo, since hyaluronan both inhibits restenosis and is anti-inflammatory. When administered to animals undergoing angioplasty the recruitment of cells into the restenotic plaque is inhibited, as well as into inflammatory l...

journal_title：Inflammopharmacology

authors： Alam CA,Seed MP,Freemantle C,Brown J,Perretti M,Carrier M,Divwedi A,West DC,Gustafson S,Colville-Nash PR,Willoughby DA

更新日期：2005-01-01 00:00:00

abstract：:Helicobacter pylori infection, as well as NSAIDs induce oxidative stress on gastric mucosa, thereby causing mucosal damage and retarding mucosal repair. Cells can survive against chronic oxidative stress by enhancing activities of anti-oxidant enzymes, thereby protecting cells from DNA damage. Recent studies have clea...

journal_title：Inflammopharmacology

authors： Yanaka A,Zhang S,Tauchi M,Suzuki H,Shibahara T,Matsui H,Nakahara A,Tanaka N,Yamamoto M

更新日期：2005-01-01 00:00:00

abstract：:The ulcerogenic effect of rofecoxib, a selective cyclooxygenase-2 (COX-2) inhibitor, on the gastrointestinal mucosa was investigated in the presence of a low dose of indomethacin. Indomethacin at 3 mg/kg did not cause any damage in both the stomach and small intestine, despite inhibiting prostaglandin (PG) production....

journal_title：Inflammopharmacology

authors： Yokota A,Taniguchi M,Tanaka A,Takeuchi K

更新日期：2005-01-01 00:00:00

abstract：:Pioglitazone, a specific ligand for peroxisome proliferator-activated receptor gamma (PPAR-gamma), was recently implicated in the control of inflammatory processes and in the modulation of the expression of various cytokines such as tumor necrosis factor alpha (TNF-alpha), but its role in the mechanism of gastric muco...

journal_title：Inflammopharmacology

authors： Brzozowski T,Konturek PC,Pajdo R,Kwiecień SN,Konturek S,Targosz A,Burnat G,Cieszkowski J,Pawlik WW,Hahn EG

更新日期：2005-01-01 00:00:00